This slow cooker meatloaf is super easy to make and stays juicy all day! Just mix your beef with some tasty spices, shape it, and let the slow cooker do the work.
My favorite part? The smell wafting through the house while it cooks—it’s like a cozy hug! Plus, leftovers make a great sandwich, so you can’t go wrong! 😋
Key Ingredients & Substitutions
Ground Beef: I recommend using 80% lean ground beef for a good balance of flavor and juiciness. If you want a lighter option, you can use ground turkey or chicken, though they may yield a drier meatloaf. Don’t forget to add some moisture!
Breadcrumbs: Regular breadcrumbs work well, but you can use panko for extra crunch, or oats for a healthier option. If you’re gluten-free, try gluten-free breadcrumbs or crushed gluten-free crackers.
Milk: Whole milk provides great moisture, but you can substitute with almond milk, soy milk, or any milk alternative if needed. Just make sure it’s unsweetened.
Cheese: I love the idea of stuffing meatloaf with mozzarella! If you can’t find mozzarella, feel free to use cheddar or a mix of your favorites for extra flavor. You can skip the cheese if you’re keeping it dairy-free.
How Do You Achieve the Perfect Meatloaf Texture?
Getting the right texture can be tricky, but here’s how to do it easily. Combine your ingredients without overmixing—this keeps the meatloaf tender. The breadcrumbs will help bind, while the milk adds moisture.
- Soak the breadcrumbs in milk first. This ensures they’re soft and can help keep the meatloaf moist.
- Use your hands to gently mix the ingredients. Overworking the meat can lead to a tough meatloaf.
- Shaping the loaf gently also helps. Try not to pack it too tightly.
Following these steps will give you a great texture that everyone will love!

How to Make Slow Cooker Meatloaf
Ingredients You’ll Need
For the Meatloaf:
- 2 pounds ground beef (80% lean)
- 1 cup breadcrumbs
- 1/2 cup milk
- 1 large egg
- 1 small onion, finely chopped
- 2 cloves garlic, minced
- 1/4 cup fresh parsley, chopped
- 1/4 cup grated Parmesan cheese
- 1 teaspoon salt
- 1/2 teaspoon black pepper
- 1 tablespoon Worcestershire sauce
- 1/2 teaspoon dried oregano
- 1 cup shredded mozzarella cheese (optional; for stuffing)
For the Glaze:
- 1/2 cup ketchup
- 2 tablespoons brown sugar
- 1 tablespoon Dijon mustard
How Much Time Will You Need?
This slow cooker meatloaf will take about 15 minutes to prep and then you’ll let it cook on low for 6-8 hours or on high for 3-4 hours. It’s easy to throw together in the morning and have a delicious dinner ready by evening!
Step-by-Step Instructions
1. Soak the Breadcrumbs
In a small bowl, add the breadcrumbs and pour the milk over them. Let this mixture sit for about 5 minutes, so the breadcrumbs can soak up the milk. This keeps the meatloaf nice and moist!
2. Make the Meat Mixture
In a large mixing bowl, combine the ground beef, the soaked breadcrumbs, the egg, chopped onion, minced garlic, parsley, Parmesan cheese, salt, pepper, Worcestershire sauce, and oregano. Mix everything gently until just combined—don’t overmix, or your meatloaf may be tough.
3. Add Cheese (Optional)
If you want to add a cheesy surprise, take half of the meat mixture and shape it into an oblong loaf on a clean surface. Spread the shredded mozzarella cheese over the top, then cover it with the other half of the meat mixture, shaping it back into a loaf.
4. Prepare the Slow Cooker
Carefully place your shaped meatloaf into the slow cooker. It should fit comfortably without touching the sides too much.
5. Make the Glaze
In a small bowl, mix together the ketchup, brown sugar, and Dijon mustard until smooth. This glaze will add a sweet and tangy flavor to your meatloaf!
6. Glaze the Meatloaf
Spoon half of the glaze over the meatloaf to infuse it with flavor while it cooks.
7. Cook Until Done
Cover the slow cooker and cook on low for 6-8 hours or on high for 3-4 hours, until the meatloaf reaches an internal temperature of 160°F (70°C). You can leave it cooking while you go about your day!
8. Final Glaze Before Serving
About 15 minutes before you’re ready to eat, spread the remaining glaze on top of the meatloaf for an extra burst of flavor.
9. Serve and Enjoy
Once done, garnish with some chopped parsley if you like. Let it sit for a few minutes before slicing. Enjoy your tender, juicy slow cooker meatloaf with a delicious glaze!
Can I Use Ground Turkey or Chicken Instead of Beef?
Absolutely! Ground turkey or chicken can be a healthier alternative, but they may produce a drier meatloaf. To counter this, consider adding extra moisture through additional milk or even some grated vegetables.
What Can I Substitute for Breadcrumbs?
If you don’t have breadcrumbs, you can use crushed crackers, oatmeal, or even ground almonds for a gluten-free option. Just make sure to adjust the consistency if needed by adding a little extra moisture or egg.
Can I Make This Meatloaf in Advance?
Yes, you can prepare the meatloaf up to a day in advance! Just mix all the ingredients, shape it into a loaf, cover it tightly, and refrigerate. When you’re ready, just pop it into the slow cooker and adjust the cooking time if it’s cold from the fridge.
How Should I Store Leftovers?
Store any leftovers in an airtight container in the fridge for up to 3-4 days. You can reheat slices in the microwave or on the stove. For best flavor, add a touch of ketchup or BBQ sauce when reheating!
